Gene

myo7ab

ID

ZDB-GENE-091110-4

Name

myosin VIIAb

Symbol

myo7ab Nomenclature History

Previous Names

si:dkey-163i6.5

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Predicted to localize to myosin complex. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Usher syndrome (multiple); auditory system disease (multiple); and congenital nystagmus. Orthologous to human MYO7A (myosin VIIA).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myo7ab Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 11	Alliance	Deafness, autosomal dominant 11	601317
autosomal recessive nonsyndromic deafness 2	Alliance	Deafness, autosomal recessive 2	600060
Usher syndrome type 1	Alliance	Usher syndrome, type 1B	276900

Associated With myo7ab Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Domain	IPR000299	FERM domain
Domain	IPR000857	MyTH4 domain
Domain	IPR001452	SH3 domain
Domain	IPR002404	IRS-type PTB domain
Domain	IPR019748	FERM central domain
Domain	IPR019749	Band 4.1 domain
Domain	IPR036106	Class VII myosin, motor domain
Domain	IPR041793	Myosin VII, FERM domain C-lobe, repeat 1
Domain	IPR041794	Myosin VII, FERM domain C-lobe, repeat 2
Family	IPR051567	Unconventional Myosin ATPase
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR014352	FERM/acyl-CoA-binding protein superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR035963	FERM superfamily, second domain
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily
Homologous_superfamily	IPR038185	MyTH4 domain superfamily

Domain Details Per Protein

Protein	Length	Band 4.1 domain	Class VII myosin, motor domain	FERM/acyl-CoA-binding protein superfamily	FERM central domain	FERM domain	FERM superfamily, second domain	IQ motif, EF-hand binding site	IRS-type PTB domain	Kinesin motor domain superfamily	Myosin VII, FERM domain C-lobe, repeat 1	Myosin VII, FERM domain C-lobe, repeat 2	MyTH4 domain	MyTH4 domain superfamily	PH-like domain superfamily	P-loop containing nucleoside triphosphate hydrolase	SH3 domain	SH3-like domain superfamily	Ubiquitin-like domain superfamily	Unconventional Myosin ATPase
UniProtKB:A0A8M9PYX7 InterPro	2177
UniProtKB:A0A8M1QV12 InterPro	2191
UniProtKB:A0A8M3AWW6 InterPro	2177
UniProtKB:A0A8M3AM80 InterPro	2204

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	myo7ab-201 (1) Ensembl	Ensembl		6,573 nt	Select Tool ZFIN BLAST
mRNA	myo7ab-202 (1) Ensembl	Ensembl		6,500 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations