Gene
tdp1
- ID
- ZDB-GENE-090909-1
- Name
- tyrosyl-DNA phosphodiesterase 1
- Symbol
- tdp1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Enables phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands. Involved in adult locomotory behavior. Predicted to be active in nucleus. Is expressed in head. Human ortholog(s) of this gene implicated in spinocerebellar ataxia with axonal neuropathy 1. Orthologous to human TDP1 (tyrosyl-DNA phosphodiesterase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Zaksauskaite et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spinocerebellar ataxia with axonal neuropathy 1 | Alliance | ?Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1 | 607250 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR010347 | Tyrosyl-DNA phosphodiesterase I |
Domain Details Per Protein
| Protein | Length | Tyrosyl-DNA phosphodiesterase I |
|---|---|---|
|
UniProtKB:F8W5U2
|
615 |
Interactions and Pathways
No data available
Plasmids
No data available