Gene
synpo2la
- ID
- ZDB-GENE-090828-4
- Name
- synaptopodin 2-like a
- Symbol
- synpo2la Nomenclature History
- Previous Names
-
- chap2 (1)
- wu:fj80h05
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable actin binding activity. Acts upstream of or within cardiac muscle tissue development and skeletal muscle tissue development. Predicted to be located in cytoplasm and organelle. Predicted to be active in Z disc; actin cytoskeleton; and nucleus. Is expressed in heart; heart tube; somite; and trunk. Orthologous to human SYNPO2L (synaptopodin 2 like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Beqqali et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-synpo2la | (2) | |
| CRISPR2-synpo2la | (2) | |
| CRISPR3-synpo2la | (2) | |
| CRISPR4-synpo2la | (2) | |
| CRISPR5-synpo2la | (2) | |
| CRISPR6-synpo2la | (2) | |
| MO1-synpo2la | N/A | Beqqali et al., 2010 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | PDZ domain | PDZ superfamily | Synaptopodin domain-containing protein |
|---|---|---|---|---|---|
| UniProtKB:A0A8N7UVB2 | InterPro | 1151 | |||
| UniProtKB:A0A8M3B845 | InterPro | 1179 | |||
| UniProtKB:F1RCC9 | InterPro | 1179 | |||
| UniProtKB:A0A140LH61 | InterPro | 1151 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
synpo2la-201
(1)
|
Ensembl | 6,606 nt | ||
| mRNA |
synpo2la-202
(1)
|
Ensembl | 6,145 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-127M24 | ||
| Contained in | BAC | DKEY-237M7 | ||
| Encodes | EST | fj80h05 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009307375 (1) | 5889 nt | ||
| Genomic | GenBank:BX324175 (1) | 222879 nt | ||
| Polypeptide | UniProtKB:A0A8M3B845 (1) | 1179 aa |
- Comparative Orthology
- Alliance
- Tamai, S., Fujita, S.I., Komine, R., Kanki, Y., Aoki, K., Watanabe, K., Takekoshi, K., Sugasawa, T. (2022) Acute cold stress induces transient MuRF1 upregulation in the skeletal muscle of zebrafish. Biochemical and Biophysical Research Communications. 608:59-65
- Pohl, J., Golovko, O., Carlsson, G., Örn, S., Schmitz, M., Ahi, E.P. (2021) Gene co-expression network analysis reveals mechanisms underlying ozone-induced carbamazepine toxicity in zebrafish (Danio rerio) embryos. Chemosphere. 276:130282
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Moreno-Mateos, M.A., Vejnar, C.E., Beaudoin, J.D., Fernandez, J.P., Mis, E.K., Khokha, M.K., Giraldez, A.J. (2015) CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo. Nature Methods. 12:982-8
- Beqqali, A., Monshouwer-Kloots, J., Monteiro, R., Welling, M., Bakkers, J., Ehler, E., Verkleij, A., Mummery, C., and Passier, R. (2010) CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function. Journal of Cell Science. 123(Pt 7):1141-1150
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