Gene
f8
- ID
- ZDB-GENE-090629-2
- Name
- coagulation factor VIII, procoagulant component
- Symbol
- f8 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor activity. Acts upstream of or within blood coagulation; glial cell development; and retina development in camera-type eye. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Used to study factor VIII deficiency. Human ortholog(s) of this gene implicated in factor VIII deficiency. Orthologous to human F8 (coagulation factor VIII).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| factor VIII deficiency | Alliance | Hemophilia A | 306700 |
| Thrombophilia 13, X-linked, due to factor VIII defect | 301071 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| factor VIII deficiency | f8sa19072/sa19072 | standard conditions | Dhinoja et al., 2024 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR033138 | Multicopper oxidases, conserved site |
| Domain | IPR000421 | Coagulation factor 5/8, C-terminal domain |
| Domain | IPR011706 | Multicopper oxidase, C-terminal |
| Family | IPR024715 | Coagulation factor 5/8-like |
| Family | IPR050633 | Neuropilin/Multicopper Oxidase/Coagulation Factor |
| Homologous_superfamily | IPR008972 | Cupredoxin |
| Homologous_superfamily | IPR008979 | Galactose-binding-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Coagulation factor 5/8, C-terminal domain | Coagulation factor 5/8-like | Cupredoxin | Galactose-binding-like domain superfamily | Multicopper oxidase, C-terminal | Multicopper oxidases, conserved site | Neuropilin/Multicopper Oxidase/Coagulation Factor |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3BEX0
|
1668 |
Interactions and Pathways
No data available
Plasmids
No data available