Gene
esyt2b
- ID
- ZDB-GENE-090615-2
- Name
- extended synaptotagmin-like protein 2b
- Symbol
- esyt2b Nomenclature History
- Previous Names
-
- fam62bb (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity and phospholipid binding activity. Predicted to act upstream of or within endoplasmic reticulum-plasma membrane tethering and lipid transport. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ESYT2 (extended synaptotagmin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa599 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa11660 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31586 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa45287 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000008 | C2 domain |
| Domain | IPR031468 | Synaptotagmin-like mitochondrial-lipid-binding domain |
| Domain | IPR037733 | Extended synaptotagmin, C2A domain |
| Domain | IPR037749 | Extended synaptotagmin, C2B domain |
| Domain | IPR037752 | Extended synaptotagmin, C-terminal C2 domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | C2 domain | C2 domain superfamily | Extended Synaptotagmin | Extended synaptotagmin, C2A domain | Extended synaptotagmin, C2B domain | Extended synaptotagmin, C-terminal C2 domain | Synaptotagmin-like mitochondrial-lipid-binding domain | Synaptotagmin, SMP domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BDU7 | InterPro | 877 | ||||||||
| UniProtKB:A0A8M9QCZ0 | InterPro | 892 | ||||||||
| UniProtKB:A0A8M1RR36 | InterPro | 858 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
esyt2b-201
(1)
|
Ensembl | 2,613 nt | ||
| mRNA |
esyt2b-202
(1)
|
Ensembl | 3,931 nt | ||
| ncRNA |
esyt2b-002
(1)
|
Ensembl | 643 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-200K18 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021477936 (1) | 3183 nt | ||
| Genomic | GenBank:CU467647 (2) | 101177 nt | ||
| Polypeptide | UniProtKB:A0A8M9QCZ0 (1) | 892 aa |
- Comparative Orthology
- Alliance
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Jiang, L., Romero-Carvajal, A., Haug, J.S., Seidel, C.W., Piotrowski, T. (2014) Gene-expression analysis of hair cell regeneration in the zebrafish lateral line. Proceedings of the National Academy of Sciences of the United States of America. 111:E1383-92
- Craxton, M. (2010) A manual collection of Syt, Esyt, Rph3a, Rph3al, Doc2, and Dblc2 genes from 46 metazoan genomes - an open access resource for neuroscience and evolutionary biology. BMC Genomics. 11:37
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