Gene

map4k3b

ID

ZDB-GENE-090428-1

Name

mitogen-activated protein kinase kinase kinase kinase 3b

Symbol

map4k3b Nomenclature History

Previous Names

map4k3
im:7159207

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable MAP kinase kinase kinase kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm. Orthologous to human MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7159207 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With map4k3b Human Ortholog

No data available

Associated With map4k3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001180	Citron homology (CNH) domain
Family	IPR021160	Mitogen-activated protein (MAP) kinase kinase kinase kinase
Family	IPR050629	STE20/SPS1-related Proline-Alanine-rich Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Citron homology (CNH) domain	Mitogen-activated protein (MAP) kinase kinase kinase kinase	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	STE20/SPS1-related Proline-Alanine-rich Kinase
UniProtKB:A0A8M3ARD5 InterPro	864
UniProtKB:A0A8M9Q6N4 InterPro	897
UniProtKB:A0A8M9Q2I4 InterPro	879

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	map4k3b-203 (1) Ensembl	Ensembl	3,175 nt	Select Tool ZFIN BLAST
ncRNA	map4k3b-002 (1) Ensembl	Ensembl	862 nt	Select Tool ZFIN BLAST
ncRNA	map4k3b-003 (1) Ensembl	Ensembl	520 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations