Gene

rufy1

ID

ZDB-GENE-090421-4

Name

RUN and FYVE domain containing 1

Symbol

rufy1 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to enable metal ion binding activity. Predicted to be involved in protein transport and regulation of endocytosis. Predicted to be active in cytoplasm. Orthologous to human RUFY1 (RUN and FYVE domain containing 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa9055	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With rufy1 Human Ortholog

No data available

Associated With rufy1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000306	FYVE zinc finger
Domain	IPR004012	RUN domain
Domain	IPR017455	Zinc finger, FYVE-related
Domain	IPR047331	RUN and FYVE domain-containing protein 1, FYVE domain
Family	IPR047335	RUN and FYVE domain-containing protein 1-3

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Domain Details Per Protein

Protein	Length	FYVE zinc finger	RUN and FYVE domain-containing protein 1-3	RUN and FYVE domain-containing protein 1, FYVE domain	RUN domain	RUN domain superfamily	Zinc finger, FYVE/PHD-type	Zinc finger, FYVE-related	Zinc finger, RING/FYVE/PHD-type
UniProtKB:E7FE23 InterPro	697

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Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 14

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	rufy1-201 (1) Ensembl	Ensembl		2,407 nt	Select Tool ZFIN BLAST
ncRNA	rufy1-002 (1) Ensembl	Ensembl		719 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH73-269I13	CU855621	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_002667315 (1)	4787 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU855621 (1)	79189 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:E7FE23 (1)	697 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	RUFY1	5	Ensembl:ENSG00000176783 Ensembl:ENSG00000284260 Gene:80230 OMIM:610327 HGNC:19760	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Rufy1	11	Ensembl:ENSMUSG00000020375 MGI:2429762 Gene:216724	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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