Gene
apbb2b
- ID
- ZDB-GENE-090313-73
- Name
- amyloid beta (A4) precursor protein-binding, family B, member 2b
- Symbol
- apbb2b Nomenclature History
- Previous Names
-
- apbb2
- si:ch211-201g8.2
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable amyloid-beta binding activity and molecular adaptor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in cytoplasm and nucleus. Is expressed in hypural. Human ortholog(s) of this gene implicated in Alzheimer's disease and cognitive disorder. Orthologous to human APBB2 (amyloid beta precursor protein binding family B member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Anderson et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la021030Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa611 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16258 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32652 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zko386a | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-apbb2b | (2) | |
| CRISPR2-apbb2b | (2) | |
| CRISPR3-apbb2b | (2) | |
| CRISPR4-apbb2b | (2) | |
| CRISPR5-apbb2b | (2) | |
| CRISPR6-apbb2b | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Amyloid beta precursor protein binding family B member 1/2/3 | PH-like domain superfamily | PTB/PI domain | WW domain | WW domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AZH4 | InterPro | 889 | |||||
| UniProtKB:A0A8M9PIS6 | InterPro | 890 | |||||
| UniProtKB:A0A8N7TDH9 | InterPro | 890 | |||||
| UniProtKB:A0A8M2BFP7 | InterPro | 211 | |||||
| UniProtKB:A0A8M9PKH7 | InterPro | 874 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
apbb2b-201
(1)
|
Ensembl | 3,326 nt | ||
| mRNA |
apbb2b-202
(1)
|
Ensembl | 2,097 nt | ||
| mRNA |
apbb2b-203
(1)
|
Ensembl | 479 nt | ||
| ncRNA |
apbb2b-002
(1)
|
Ensembl | 527 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-195F22 | ZFIN Curated Data | |
| Contained in | BAC | CH211-201G8 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068217988 (1) | 9260 nt | ||
| Genomic | GenBank:BX119979 (1) | 194023 nt | ||
| Polypeptide | UniProtKB:A0A8M2BFP9 (1) | 892 aa |
- Anderson, R.A., Schwalbach, K.T., Mui, S.R., LeClair, E.E., Topczewska, J.M., Topczewski, J. (2020) Zebrafish models of skeletal dysplasia induced by cholesterol biosynthesis deficiency. Disease models & mechanisms. 13(6):
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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