Gene
map3k1
- ID
- ZDB-GENE-090313-412
- Name
- mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
- Symbol
- map3k1 Nomenclature History
- Previous Names
-
- si:rp71-80a19.2
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Predicted to be involved in several processes, including activation of protein kinase activity; signal transduction by protein phosphorylation; and stress-activated protein kinase signaling cascade. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in 46,XY sex reversal 6 and breast cancer. Orthologous to human MAP3K1 (mitogen-activated protein kinase kinase kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| 46,XY sex reversal 6 | Alliance | 46XY sex reversal 6 | 613762 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR007527 | Zinc finger, SWIM-type |
| Family | IPR050538 | Mitogen-activated protein kinase kinase kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
Domain Details Per Protein
| Protein | Length | Armadillo-like helical | Armadillo-type fold | Mitogen-activated protein kinase kinase kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, SWIM-type |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B1Q9
|
1479 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
map3k1-201
(1)
|
Ensembl | 3,885 nt | ||
| mRNA |
map3k1-202
(1)
|
Ensembl | 4,122 nt | ||
| mRNA |
map3k1-203
(1)
|
Ensembl | 3,909 nt |
Interactions and Pathways
No data available
Plasmids
No data available