Gene

lca5

ID

ZDB-GENE-090313-268

Name

lebercilin LCA5

Symbol

lca5 Nomenclature History

Previous Names

si:dkey-241o6.2

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Involved in photoreceptor cell maintenance and photoreceptor cell outer segment organization. Predicted to be active in axoneme. Used to study Leber congenital amaurosis. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 5. Orthologous to human LCA5 (lebercilin LCA5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from Qu et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lca5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Leber congenital amaurosis 5	Alliance	Leber congenital amaurosis 5	604537

Associated With lca5 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Leber congenital amaurosis	lca5^{zf3156/zf3156}	standard conditions	Qu et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR028933	Lebercilin domain
Family	IPR026188	Lebercilin-like

Domain Details Per Protein

Protein	Length	Lebercilin domain	Lebercilin-like
UniProtKB:A0A8M9PLA8 InterPro	755
UniProtKB:A0A8M9P5L0 InterPro	766
UniProtKB:A0A8M3AVL5 InterPro	754
UniProtKB:E9QG33 InterPro	754
UniProtKB:A0A8M9PTN2 InterPro	753
UniProtKB:A0A8M6Z3Y4 InterPro	766
UniProtKB:A0A8M9Q832 InterPro	766
UniProtKB:A0A8M9PTM7 InterPro	767
UniProtKB:A0A8M6YVF9 InterPro	767
UniProtKB:A0A8M3AYN7 InterPro	755
UniProtKB:A0A8M6YW27 InterPro	753
UniProtKB:A0A8M9PFL3 InterPro	766

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	lca5-201 (1) Ensembl	Ensembl		2,220 nt	Select Tool ZFIN BLAST
mRNA	lca5-202 (1) Ensembl	Ensembl		2,690 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations