Gene
spp2
- ID
- ZDB-GENE-090313-223
- Name
- secreted phosphoprotein 2
- Symbol
- spp2 Nomenclature History
- Previous Names
-
- si:dkey-1h24.4
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to be located in extracellular region. Is expressed in cranium. Orthologous to human SPP2 (secreted phosphoprotein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Kessels et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zko566a | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystatin superfamily | Secreted phosphoprotein 24 |
|---|---|---|---|---|
| UniProtKB:A0A8M1P445 | InterPro | 194 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-1H24 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001327983 (1) | |||
| Genomic | RefSeq:NW_018394489 (1) | |||
| Polypeptide | UniProtKB:A0A8M1P445 (1) | 194 aa |
No data available
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Liu, Y., Chen, X., Xu, Q., Gao, X., Tam, P.O., Zhao, K., Zhang, X., Chen, L.J., Jia, W., Zhao, Q., Vollrath, D., Pang, C.P., Zhao, C. (2015) SPP2 Mutations Cause Autosomal Dominant Retinitis Pigmentosa. Scientific Reports. 5:14867
- Kessels, M.Y., Huitema, L.F., Boeren, S., Kranenbarg, S., Schulte-Merker, S., van Leeuwen, J.L., de Vries, S.C. (2014) Proteomics analysis of the zebrafish skeletal extracellular matrix. PLoS One. 9:e90568
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