Gene
slc4a11
- ID
- ZDB-GENE-090313-183
- Name
- solute carrier family 4 member 11
- Symbol
- slc4a11 Nomenclature History
- Previous Names
-
- si:dkey-12j14.4
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic ion homeostasis and transmembrane transport. Predicted to act upstream of or within monoatomic anion transport. Predicted to be located in membrane. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including eye; gill; heart; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy; congenital hereditary endothelial dystrophy of cornea; and corneal dystrophy-perceptive deafness syndrome. Orthologous to human SLC4A11 (solute carrier family 4 member 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Lee et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la027385Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa35444 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38927 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital hereditary endothelial dystrophy of cornea | Alliance | Corneal endothelial dystrophy, autosomal recessive | 217700 |
| corneal dystrophy-perceptive deafness syndrome | Alliance | Corneal endothelial dystrophy and perceptive deafness | 217400 |
| Fuchs' endothelial dystrophy | Alliance | Corneal dystrophy, Fuchs endothelial, 4 | 613268 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Bicarbonate transporter, eukaryotic | Bicarbonate transporter-like, transmembrane domain | Phosphotransferase/anion transporter |
|---|---|---|---|---|
|
UniProtKB:A0A8M1NRH1
|
846 | |||
|
UniProtKB:A0A8M2B2N8
|
877 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc4a11-201
(1)
|
Ensembl | 2,798 nt | ||
| mRNA |
slc4a11-202
(1)
|
Ensembl | 2,349 nt | ||
| mRNA |
slc4a11-203
(1)
|
Ensembl | 2,457 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-194C3 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-12J14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-170I22 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001159828 (1) | 2541 nt | ||
| Genomic | GenBank:CR788322 (1) | 234400 nt | ||
| Polypeptide | UniProtKB:A0A8M2B2N8 (1) | 877 aa |
- Li, N., Gao, S., Wang, S., He, S., Wang, J., He, L., Jiang, D., Shi, Y.S., Zhang, J., Gu, Y., Chen, T., Kong, M., Xu, X., Zhao, Q. (2021) Attractin Participates in Schizophrenia by Affecting Testosterone Levels. Frontiers in cell and developmental biology. 9:755165
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Lee, Y.C., Yan, J.J., Cruz, S., Horng, J.L., and Hwang, P.P. (2011) Anion exchanger 1b, but not sodium-bicarbonate cotransporter 1b, plays a role in transport functions of zebrafish H+-ATPase-rich cells. American journal of physiology. Cell physiology. 300(2):C295-C307
- Terbach, N., Shah, R., Kelemen, R., Klein, P.S., Gordienko, D., Brown, N.A., Wilkinson, C.J., and Williams, R.S. (2011) Identifying an uptake mechanism for the antiepileptic and bipolar disorder treatment valproic acid using the simple biomedical model Dictyostelium. Journal of Cell Science. 124(Pt 13):2267-76
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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