Gene

trim2b

ID

ZDB-GENE-090312-70

Name

tripartite motif containing 2b

Symbol

trim2b Nomenclature History

Previous Names

si:dkeyp-75b4.11
trim2like (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2R. Orthologous to human TRIM2 (tripartite motif containing 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With trim2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Charcot-Marie-Tooth disease type 2R	Alliance	Charcot-Marie-Tooth disease, type 2R	615490

Associated With trim2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000315	B-box-type zinc finger
Domain	IPR003649	B-box, C-terminal
Family	IPR050952	Tripartite Motif and NHL Repeat Containing E3 Ligases
Homologous_superfamily	IPR011042	Six-bladed beta-propeller, TolB-like
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR014756	Immunoglobulin E-set
Repeat	IPR001258	NHL repeat
Repeat	IPR001298	Filamin/ABP280 repeat
Repeat	IPR017868	Filamin/ABP280 repeat-like

Domain Details Per Protein

Protein	Length	B-box, C-terminal	B-box-type zinc finger	Filamin/ABP280 repeat	Filamin/ABP280 repeat-like	Immunoglobulin E-set	Immunoglobulin-like fold	NHL repeat	Six-bladed beta-propeller, TolB-like	Tripartite Motif and NHL Repeat Containing E3 Ligases
UniProtKB:B8A5M1 InterPro	669

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	trim2b-201 (1) Ensembl	Ensembl	2,877 nt	Select Tool ZFIN BLAST
mRNA	trim2b-202 (1) Ensembl	Ensembl	2,587 nt	Select Tool ZFIN BLAST
mRNA	trim2b-203 (1) Ensembl	Ensembl	2,591 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations