Gene

map3k21

ID

ZDB-GENE-090312-24

Name

mitogen-activated protein kinase kinase kinase 21

Symbol

map3k21 Nomenclature History

Previous Names

si:ch211-120p12.3 (1)

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have JUN kinase kinase kinase activity. Predicted to be involved in activation of JUN kinase activity. Orthologous to human MAP3K21 (mitogen-activated protein kinase kinase kinase 21).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With map3k21 Human Ortholog

No data available

Associated With map3k21 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR001452	SH3 domain
Domain	IPR035779	MLK1-3, SH3 domain
Family	IPR016231	Mitogen-activated protein (MAP) kinase kinase kinase, MLK1-4
Family	IPR050167	Serine/threonine-protein kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily

Domain Details Per Protein

Protein	Length	Mitogen-activated protein (MAP) kinase kinase kinase, MLK1-4	MLK1-3, SH3 domain	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase	Serine/threonine-protein kinase, active site	Serine-threonine/tyrosine-protein kinase, catalytic domain	SH3 domain	SH3-like domain superfamily
UniProtKB:A0A2R8RXI8 InterPro	1017
UniProtKB:A0A8N7UQZ3 InterPro	982

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	map3k21-201 (1) Ensembl	Ensembl	3,109 nt	Select Tool
mRNA	map3k21-202 (1) Ensembl	Ensembl	3,754 nt	Select Tool ZFIN BLAST
mRNA	map3k21-203 (1) Ensembl	Ensembl	3,982 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations