Gene

npnta

ID

ZDB-GENE-090312-201

Name

nephronectin a

Symbol

npnta Nomenclature History

Previous Names

npnt
si:ch211-202n8.2

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity. Involved in atrioventricular valve development and heart trabecula formation. Predicted to localize to membrane. Used to study membranous glomerulonephritis and proteinuria. Is expressed in several structures, including digestive system; endoderm; head; heart; and tail bud. Orthologous to human NPNT (nephronectin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With npnta Human Ortholog

No data available

Associated With npnta Via Experimental Models

Human Disease	Fish	Conditions	Citations
proteinuria	WT + MO2-npnta	standard conditions	Müller-Deile et al., 2017
membranous glomerulonephritis	WT + MO2-npnta	standard conditions	Müller-Deile et al., 2017

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR000998	MAM domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR024731	EGF domain
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site

Domain Details Per Protein

Protein	Length	Concanavalin A-like lectin/glucanase domain superfamily	EGF domain	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	Growth factor receptor cysteine-rich domain superfamily	MAM domain
UniProtKB:A0A8M2B6Z0 InterPro	619
UniProtKB:A0A8M3AVI7 InterPro	588
UniProtKB:B8A5G4 InterPro	605
UniProtKB:A0A8M3B3H9 InterPro	636

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	npnt-201 (1) Ensembl	Havana	2441 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	npnt-202 (1) Ensembl	Havana	431 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	npnt-003 (1) Ensembl	Havana	547 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations