Gene
gsk3bb
- ID
- ZDB-GENE-090312-2
- Name
- glycogen synthase kinase 3 beta, genome duplicate b
- Symbol
- gsk3bb Nomenclature History
- Previous Names
-
- si:dkeyp-80c12.7
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable beta-catenin binding activity; protein serine/threonine kinase activity; and tau-protein kinase activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; and regulation of microtubule cytoskeleton organization. Predicted to act upstream of or within protein phosphorylation and rhythmic process. Predicted to be located in plasma membrane. Predicted to be part of beta-catenin destruction complex. Predicted to be active in several cellular components, including axon; cytosol; and glutamatergic synapse. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; oral squamous cell carcinoma; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR039192 | Glycogen synthase kinase 3, catalytic domain |
| Family | IPR050591 | Glycogen Synthase Kinase-3 |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Glycogen Synthase Kinase-3 | Glycogen synthase kinase 3, catalytic domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:B8JIQ1
|
419 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gsk3b (1 of many)-201
(1)
|
Ensembl | 1,260 nt | ||
| ncRNA |
si:dkeyp-80c12.7-002
(1)
|
Ensembl | 428 nt |
Interactions and Pathways
No data available
Plasmids
No data available