Gene
uba6
- ID
- ZDB-GENE-090312-139
- Name
- ubiquitin like modifier activating enzyme 6
- Symbol
- uba6 Nomenclature History
- Previous Names
-
- si:dkey-82j4.2
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable FAT10 activating enzyme activity and ubiquitin activating enzyme activity. Predicted to be involved in DNA damage response; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm and nucleus. Is expressed in hypural. Orthologous to human UBA6 (ubiquitin like modifier activating enzyme 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Anderson et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000594 | THIF-type NAD/FAD binding fold |
| Domain | IPR018965 | Ubiquitin-activating enzyme E1, C-terminal |
| Domain | IPR019572 | Ubiquitin-activating enzyme, SCCH domain |
| Domain | IPR032418 | Ubiquitin-activating enzyme E1, FCCH domain |
| Domain | IPR032420 | Ubiquitin-activating enzyme E1, four-helix bundle |
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Domain Details Per Protein
| Protein | Additional Resources | Length | ThiF/MoeB/HesA family | THIF-type NAD/FAD binding fold | Ubiquitin-activating enzyme E1 | Ubiquitin-activating enzyme E1, C-terminal | Ubiquitin-activating enzyme E1, C-terminal domain superfamily | Ubiquitin-activating enzyme E1, FCCH domain | Ubiquitin-activating enzyme E1, FCCH domain superfamily | Ubiquitin-activating enzyme E1, four-helix bundle | Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 | Ubiquitin-activating enzyme E1, SCCH domain | Ubiquitin-activating enzyme, SCCH domain | Ubiquitin/SUMO-activating enzyme E1-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PY01 | InterPro | 1027 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:dkey-82j4.2-201
(1)
|
Ensembl | 3,427 nt | ||
| mRNA |
uba6-202
(1)
|
Ensembl | 3,063 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-82J4 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021476288 (1) | |||
| Genomic | GenBank:BX119979 (1) | 194023 nt | ||
| Polypeptide | UniProtKB:A0A8M9PY01 (1) | 1027 aa |
- Comparative Orthology
- Alliance
- Liu, S., Hu, G., Luo, S., Wu, W., Zhou, Q., Jin, R., Zhang, Y., Ruan, H., Huang, H., Li, H. (2022) Insights into the evolution of the ISG15 and UBA7 system. Genomics. 114(2):110302
- Anderson, R.A., Schwalbach, K.T., Mui, S.R., LeClair, E.E., Topczewska, J.M., Topczewski, J. (2020) Zebrafish models of skeletal dysplasia induced by cholesterol biosynthesis deficiency. Disease models & mechanisms. 13(6):
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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