Gene

dnah12

ID

ZDB-GENE-090311-9

Name

dynein, axonemal, heavy chain 12

Symbol

dnah12 Nomenclature History

Previous Names

si:ch73-289a15.4

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have ATP-dependent microtubule motor activity, minus-end-directed; dynein intermediate chain binding activity; and dynein light intermediate chain binding activity. Predicted to be involved in cilium movement. Predicted to localize to inner dynein arm. Orthologous to human DNAH12 (dynein axonemal heavy chain 12).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dnah12 Human Ortholog

No data available

Associated With dnah12 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR004273	Dynein heavy chain region D6 P-loop domain
Domain	IPR013602	Dynein heavy chain, linker
Domain	IPR024317	Dynein heavy chain, AAA module D4
Domain	IPR024743	Dynein heavy chain, coiled coil stalk
Domain	IPR035699	Dynein heavy chain, hydrolytic ATP-binding dynein motor region
Domain	IPR035706	Dynein heavy chain, ATP-binding dynein motor region
Domain	IPR041228	Dynein heavy chain, C-terminal domain
Domain	IPR041466	Dynein heavy chain, AAA 5 extension domain
Domain	IPR041589	Dynein heavy chain 3, AAA+ lid domain
Domain	IPR041658	Dynein heavy chain AAA lid domain
Family	IPR026983	Dynein heavy chain
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR042219	Dynein heavy chain AAA lid domain superfamily
Homologous_superfamily	IPR042222	Dynein heavy chain, domain 2, N-terminal
Homologous_superfamily	IPR042228	Dynein heavy chain, linker, subdomain 3
Homologous_superfamily	IPR043157	Dynein heavy chain, AAA1 domain, small subdomain
Homologous_superfamily	IPR043160	Dynein heavy chain, C-terminal domain, barrel region

Domain Details Per Protein

Protein	Length	AAA+ ATPase domain	Dynein heavy chain	Dynein heavy chain 3, AAA+ lid domain	Dynein heavy chain, AAA1 domain, small subdomain	Dynein heavy chain, AAA 5 extension domain	Dynein heavy chain AAA lid domain	Dynein heavy chain AAA lid domain superfamily	Dynein heavy chain, AAA module D4	Dynein heavy chain, ATP-binding dynein motor region	Dynein heavy chain, coiled coil stalk	Dynein heavy chain, C-terminal domain	Dynein heavy chain, C-terminal domain, barrel region	Dynein heavy chain, domain 2, N-terminal	Dynein heavy chain, hydrolytic ATP-binding dynein motor region	Dynein heavy chain, linker	Dynein heavy chain, linker, subdomain 3	Dynein heavy chain region D6 P-loop domain	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M9PZ60 InterPro	3969
UniProtKB:A0A8M9Q7R5 InterPro	3220
UniProtKB:A0A8M9P5E8 InterPro	3969

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dnah12-201 (1) Ensembl	Ensembl	11,637 nt	Select Tool ZFIN BLAST
mRNA	dnah12-202 (1) Ensembl	Ensembl	12,060 nt	Select Tool
mRNA	dnah12-203 (1) Ensembl	Ensembl	8,904 nt	Select Tool ZFIN BLAST
mRNA	dnah12-204 (1) Ensembl	Ensembl	8,964 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations