Gene
spock3
- ID
- ZDB-GENE-090311-24
- Name
- SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
- Symbol
- spock3 Nomenclature History
- Previous Names
-
- im:7139568
- si:dkey-285b22.1
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity; collagen binding activity; and extracellular matrix binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in cardiovascular system; hypural; nervous system; and neural tube. Orthologous to human SPOCK3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7139568 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| nu83 | Allele with one delins | Unknown | Unknown | CRISPR | |
| sa11967 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17392 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa39600 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zko394a | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-spock3 | China Zebrafish Resource Center (CZRC) | |
| CRISPR2-spock3 | Anderson et al., 2020 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
| Domain | IPR000716 | Thyroglobulin type-1 |
| Domain | IPR002350 | Kazal domain |
| Domain | IPR019577 | SPARC/Testican, calcium-binding domain |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR036058 | Kazal domain superfamily |
| Homologous_superfamily | IPR036857 | Thyroglobulin type-1 superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | EF-Hand 1, calcium-binding site | EF-hand domain pair | Kazal domain | Kazal domain superfamily | SPARC/Testican, calcium-binding domain | Thyroglobulin type-1 | Thyroglobulin type-1 superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IMY5 | InterPro | 387 | |||||||
| UniProtKB:F1RAX3 | InterPro | 384 | |||||||
| UniProtKB:A0A8M6YZL5 | InterPro | 386 | |||||||
| UniProtKB:A0A8M3BEW5 | InterPro | 389 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
spock3-201
(1)
|
Ensembl | 2,459 nt | ||
| mRNA |
spock3-202
(1)
|
Ensembl | 1,039 nt | ||
| mRNA |
spock3-203
(1)
|
Ensembl | 971 nt | ||
| mRNA |
spock3-204
(1)
|
Ensembl | 1,322 nt | ||
| mRNA |
spock3-205
(1)
|
Ensembl | 1,164 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-142C4 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-285B22 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7139568 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001327987 (1) | 2573 nt | ||
| Genomic | GenBank:CR381587 (1) | 169210 nt | ||
| Polypeptide | UniProtKB:A0A8M3BEW5 (1) | 389 aa |
- Dong, Y., Yang, Y., Wang, H., Feng, D., Nist, E., Yapundich, N., Spurlock, B., Craft, M., Qian, L., Liu, J. (2024) Single-cell chromatin profiling reveals genetic programs activating proregenerative states in nonmyocyte cells. Science advances. 10:eadk4694
- Denans, N., Tran, N.T.T., Swall, M.E., Diaz, D.C., Blanck, J., Piotrowski, T. (2022) An anti-inflammatory activation sequence governs macrophage transcriptional dynamics during tissue injury in zebrafish. Nature communications. 13:5356
- Anderson, R.A., Schwalbach, K.T., Mui, S.R., LeClair, E.E., Topczewska, J.M., Topczewski, J. (2020) Zebrafish models of skeletal dysplasia induced by cholesterol biosynthesis deficiency. Disease models & mechanisms. 13(6):
- Gomez, G.A., Veldman, M.B., Zhao, Y., Burgess, S., and Lin, S. (2009) Discovery and characterization of novel vascular and hematopoietic genes downstream of etsrp in zebrafish. PLoS One. 4(3):e4994
- Renn, J., Schaedel, M., Volff, J.N., Goerlich, R., Schartl, M., and Winkler, C. (2006) Dynamic expression of sparc precedes formation of skeletal elements in the Medaka (Oryzias latipes). Gene. 372:208-218
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