Gene
ghrhrl
- ID
- ZDB-GENE-090211-1
- Name
- growth hormone releasing hormone receptor, like
- Symbol
- ghrhrl Nomenclature History
- Previous Names
-
- GHRHR (1)
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity; growth factor binding activity; and peptide hormone binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and positive regulation of cell population proliferation. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain; eye; gut; integument; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in isolated growth hormone deficiency and isolated growth hormone deficiency type IB. Orthologous to human GHRHR (growth hormone releasing hormone receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Wu et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR017983 | GPCR, family 2, secretin-like, conserved site |
Domain | IPR001879 | GPCR, family 2, extracellular hormone receptor domain |
Domain | IPR017981 | GPCR, family 2-like, 7TM |
Family | IPR000832 | GPCR, family 2, secretin-like |
Family | IPR001771 | GPCR, family 2, vasoactive intestinal peptide receptor 1 |
Family | IPR050332 | G-protein coupled receptor 2 |
Homologous_superfamily | IPR036445 | GPCR family 2, extracellular hormone receptor domain superfamily |
Domain Details Per Protein
Protein | Additional Resources | Length | GPCR, family 2, extracellular hormone receptor domain | GPCR family 2, extracellular hormone receptor domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPCR, family 2, secretin-like, conserved site | GPCR, family 2, vasoactive intestinal peptide receptor 1 | G-protein coupled receptor 2 |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A182 | InterPro | 445 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
ghrhrl-201
(1)
|
Ensembl | 512 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | Fosmid | CH1073-326E18 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001082482 (1) | 1529 nt | ||
Genomic | GenBank:FQ790213 (1) | 59581 nt | ||
Polypeptide | UniProtKB:A0A182 (1) | 445 aa |
No data available
- On, J.S.W., Duan, C., Lee, L.T.O. (2015) Functional pairing of class B1 ligand-GPCR in cephalochordate provides evidence of the origin of PTH and PACAP/glucagonreceptor family. Molecular Biology and Evolution. 32(8):2048-59
- Tam, J.K., Chow, B.K., and Lee, L.T. (2013) Structural and functional divergence of growth hormone-releasing hormone receptors in early sarcopterygians: lungfish and Xenopus. PLoS One. 8(1):e53482
- Wu, S., Roch, G., Cervini, L., Rivier, J., and Sherwood, N. (2008) Newly-identified receptors for PHI and GHRH-like peptide in zebrafish help to elucidate the mammalian secretin superfamily. Journal of molecular endocrinology. 41(5):343-366
- Lee, L.T., Siu, F.K., Tam, J.K., Lau, I.T., Wong, A.O., Lin, M.C., Vaudry, H., and Chow, B.K. (2007) Discovery of growth hormone-releasing hormones and receptors in nonmammalian vertebrates. Proceedings of the National Academy of Sciences of the United States of America. 104(7):213-2138
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