Gene

anapc1

ID

ZDB-GENE-081107-12

Name

anaphase promoting complex subunit 1

Symbol

anapc1 Nomenclature History

Previous Names

si:ch211-160m22.1 (1)

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process; metaphase/anaphase transition of mitotic cell cycle; and protein K11-linked ubiquitination. Predicted to localize to anaphase-promoting complex. Human ortholog(s) of this gene implicated in Rothmund-Thomson syndrome. Orthologous to human ANAPC1 (anaphase promoting complex subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With anapc1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Rothmund-Thomson syndrome, type 1	618625

Associated With anapc1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR041221	Anaphase-promoting complex subunit 1, C-terminal
Domain	IPR046794	Anaphase-promoting complex subunit 1, middle domain
Domain	IPR048971	Anaphase-promoting complex subunit 1, beta-sandwich domain
Domain	IPR049255	Anaphase-promoting complex subunit 1, N-terminal domain
Family	IPR024990	Anaphase-promoting complex subunit 1
Homologous_superfamily	IPR011989	Armadillo-like helical

Domain Details Per Protein

Protein	Length	Anaphase-promoting complex subunit 1	Anaphase-promoting complex subunit 1, beta-sandwich domain	Anaphase-promoting complex subunit 1, C-terminal	Anaphase-promoting complex subunit 1, middle domain	Anaphase-promoting complex subunit 1, N-terminal domain	Armadillo-like helical
UniProtKB:A0A2R8QA59 InterPro	1932
UniProtKB:A0A8M1QKJ8 InterPro	1931
UniProtKB:A0A8M9QG54 InterPro	1927
UniProtKB:A0A8M2B3F5 InterPro	1928

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	anapc1-201 (1) Ensembl	Ensembl	6,047 nt	Select Tool ZFIN BLAST
mRNA	anapc1-202 (1) Ensembl	Ensembl	1,694 nt	Select Tool
mRNA	anapc1-204 (1) Ensembl	Ensembl	4,246 nt	Select Tool
mRNA	anapc1-206 (1) Ensembl	Ensembl	8,854 nt	Select Tool ZFIN BLAST
mRNA	anapc1-207 (1) Ensembl	Ensembl	8,929 nt	Select Tool ZFIN BLAST
ncRNA	anapc1-003 (1) Ensembl	Ensembl	702 nt	Select Tool
ncRNA	anapc1-004 (1) Ensembl	Ensembl	539 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations