Gene

brip1

ID

ZDB-GENE-081107-11

Name

BRCA1 interacting helicase 1

Symbol

brip1 Nomenclature History

Previous Names

fancj (1)
Fanconi anemia, complementation group J
si:ch211-158l18.1

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to have DNA helicase activity. Predicted to be involved in double-strand break repair involved in meiotic recombination and nucleotide-excision repair. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group J; breast cancer; colorectal cancer; and thrombocytopenia. Is expressed in central nervous system; lens; oral epithelium; and pectoral fin fold. Orthologous to human BRIP1 (BRCA1 interacting protein C-terminal helicase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from Titus et al., 2009

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Ramanagoudr-Bhojappa et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With brip1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
breast cancer	Alliance	{Breast cancer, early-onset, susceptibility to}	114480
Fanconi anemia complementation group J	Alliance	Fanconi anemia, complementation group J	609054

Associated With brip1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006554	Helicase-like, DEXD box c2 type
Domain	IPR006555	ATP-dependent helicase, C-terminal
Domain	IPR010614	RAD3-like helicase, DEAD
Domain	IPR014001	Helicase superfamily 1/2, ATP-binding domain
Domain	IPR014013	Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type
Family	IPR013020	ATP-dependent helicase Rad3/Chl1-like
Family	IPR045028	Helicase superfamily 1/2, DinG/Rad3-like
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	ATP-dependent helicase, C-terminal	ATP-dependent helicase Rad3/Chl1-like	Helicase-like, DEXD box c2 type	Helicase superfamily 1/2, ATP-binding domain	Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type	Helicase superfamily 1/2, DinG/Rad3-like	P-loop containing nucleoside triphosphate hydrolase	RAD3-like helicase, DEAD
UniProtKB:A0A8M9PC39 InterPro	1203
UniProtKB:B7ZDD5 InterPro	1216
UniProtKB:A0A8M9PL91 InterPro	760

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	brip1-201 (1) Ensembl	Ensembl	3,918 nt	Select Tool ZFIN BLAST
mRNA	brip1-202 (1) Ensembl	Ensembl	649 nt	Select Tool ZFIN BLAST
mRNA	brip1-203 (1) Ensembl	Ensembl	4,294 nt	Select Tool ZFIN BLAST
mRNA	brip1-204 (1) Ensembl	Ensembl	4,219 nt	Select Tool ZFIN BLAST
mRNA	brip1-205 (1) Ensembl	Ensembl	6,948 nt	Select Tool ZFIN BLAST
mRNA	brip1-206 (1) Ensembl	Ensembl	3,933 nt	Select Tool ZFIN BLAST
mRNA	brip1-207 (1) Ensembl	Ensembl	4,184 nt	Select Tool ZFIN BLAST
mRNA	brip1-208 (1) Ensembl	Ensembl	4,620 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations