Gene
brip1
- ID
- ZDB-GENE-081107-11
- Name
- BRCA1 interacting helicase 1
- Symbol
- brip1 Nomenclature History
- Previous Names
-
- fancj (1)
- Fanconi anemia, complementation group J
- si:ch211-158l18.1
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to have DNA helicase activity. Predicted to be involved in double-strand break repair involved in meiotic recombination and nucleotide-excision repair. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group J; breast cancer; colorectal cancer; and thrombocytopenia. Is expressed in central nervous system; lens; oral epithelium; and pectoral fin fold. Orthologous to human BRIP1 (BRCA1 interacting protein C-terminal helicase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Titus et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Ramanagoudr-Bhojappa et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| breast cancer | Alliance | {Breast cancer, early-onset, susceptibility to} | 114480 |
| Fanconi anemia complementation group J | Alliance | Fanconi anemia, complementation group J | 609054 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006554 | Helicase-like, DEXD box c2 type |
| Domain | IPR006555 | ATP-dependent helicase, C-terminal |
| Domain | IPR010614 | RAD3-like helicase, DEAD |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR014013 | Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type |
| Family | IPR013020 | ATP-dependent helicase Rad3/Chl1-like |
| Family | IPR045028 | Helicase superfamily 1/2, DinG/Rad3-like |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | ATP-dependent helicase, C-terminal | ATP-dependent helicase Rad3/Chl1-like | Helicase-like, DEXD box c2 type | Helicase superfamily 1/2, ATP-binding domain | Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type | Helicase superfamily 1/2, DinG/Rad3-like | P-loop containing nucleoside triphosphate hydrolase | RAD3-like helicase, DEAD |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PC39
|
1203 | ||||||||
|
UniProtKB:B7ZDD5
|
1216 | ||||||||
|
UniProtKB:A0A8M9PL91
|
760 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
brip1-201
(1)
|
Ensembl | 3,918 nt | ||
| mRNA |
brip1-202
(1)
|
Ensembl | 649 nt | ||
| mRNA |
brip1-203
(1)
|
Ensembl | 4,294 nt | ||
| mRNA |
brip1-204
(1)
|
Ensembl | 4,219 nt | ||
| mRNA |
brip1-205
(1)
|
Ensembl | 6,948 nt | ||
| mRNA |
brip1-206
(1)
|
Ensembl | 3,933 nt | ||
| mRNA |
brip1-207
(1)
|
Ensembl | 4,184 nt | ||
| mRNA |
brip1-208
(1)
|
Ensembl | 4,620 nt |
Interactions and Pathways
No data available
Plasmids
No data available