Gene

syn1

ID

ZDB-GENE-081105-93

Name

synapsin I

Symbol

syn1 Nomenclature History

Previous Names

si:dkey-90n12.3 (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have ATP binding activity. Predicted to be involved in neurotransmitter secretion. Predicted to localize to synaptic vesicle membrane. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Is expressed in DEL; nervous system; spinal cord neural tube; and yolk syncytial layer. Orthologous to human SYN1 (synapsin I).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With syn1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
non-syndromic X-linked intellectual disability 50	Alliance	Intellectual developmental disorder, X-linked 50	300115
X-linked epilepsy with variable learning disabilities and behavior disorders	Alliance	Epilepsy, X-linked 1, with variable learning disabilities and behavior disorders	300491

Associated With syn1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019735	Synapsin, conserved site
Domain	IPR020897	Synapsin, pre-ATP-grasp domain
Domain	IPR020898	Synapsin, ATP-binding domain
Family	IPR001359	Synapsin
Homologous_superfamily	IPR013815	ATP-grasp fold, subdomain 1
Homologous_superfamily	IPR016185	Pre-ATP-grasp domain superfamily
PTM	IPR019736	Synapsin, phosphorylation site