Gene

mhc2d8.46a

ID
ZDB-GENE-081105-52
Name
major histocompatibility complex class II d8.46a
Symbol
mhc2d8.46a Nomenclature History
Previous Names
  • si:ch73-211l2.3 (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to be involved in antigen processing and presentation and immune response. Predicted to localize to MHC class II protein complex and integral component of membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); bone inflammation disease (multiple); glucose metabolism disease (multiple); hematologic cancer (multiple); and liver disease (multiple). Orthologous to several human genes including HLA-DOA (major histocompatibility complex, class II, DO alpha); HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1); and HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mhc2d8.46a Human Ortholog
No data available
Associated With mhc2d8.46a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
Domain IPR001003 MHC class II, alpha chain, N-terminal
Domain IPR003597 Immunoglobulin C1-set
Domain IPR007110 Immunoglobulin-like domain
Family IPR050160 Major Histocompatibility Complex/Immunoglobulin
Homologous_superfamily IPR011162 MHC classes I/II-like antigen recognition protein
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR014745 MHC class II, alpha/beta chain, N-terminal
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin C1-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin/major histocompatibility complex, conserved site Major Histocompatibility Complex/Immunoglobulin MHC classes I/II-like antigen recognition protein MHC class II, alpha/beta chain, N-terminal MHC class II, alpha chain, N-terminal
UniProtKB:M9MM93 234
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA si:ch73-211l2.3-201 (1) Ensembl 1,221 nt
mRNA si:ch73-211l2.3-203 (1) Ensembl 699 nt
ncRNA si:ch73-211l2.3-002 (1) Ensembl 785 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations