Gene
bub1
- ID
- ZDB-GENE-081104-75
- Name
- BUB1 mitotic checkpoint serine/threonine kinase
- Symbol
- bub1 Nomenclature History
- Previous Names
-
- si:ch1073-192f24.1
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have protein kinase activity. Predicted to be involved in meiotic sister chromatid cohesion, centromeric and mitotic spindle assembly checkpoint. Predicted to localize to condensed nuclear chromosome kinetochore. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human BUB1 (BUB1 mitotic checkpoint serine/threonine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colorectal cancer with chromosomal instability, somatic | 114500 |
| Microcephaly 30, primary, autosomal recessive | 620183 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR013212 | Mad3/Bub1 homology region 1 |
| Family | IPR015661 | Mitotic spindle checkpoint protein Bub1/Mad3 |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Mad3/Bub1 homology region 1 | Mitotic spindle checkpoint protein Bub1/Mad3 | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|
|
UniProtKB:F1QNS6
|
1202 | |||||
|
UniProtKB:A0A8M9PPS7
|
1163 |
Interactions and Pathways
No data available
Plasmids
No data available