Gene

arhgef16

ID

ZDB-GENE-081104-446

Name

Rho guanine nucleotide exchange factor (GEF) 16

Symbol

arhgef16 Nomenclature History

Previous Names

si:dkeyp-100a1.3 (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of actin cytoskeleton organization. Predicted to be located in cell projection. Orthologous to human ARHGEF16 (Rho guanine nucleotide exchange factor 16).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arhgef16 Human Ortholog

No data available

Associated With arhgef16 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001452	SH3 domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR035797	ARHGEF16/ARHGEF26, SH3 domain
Domain	IPR047270	Ephexin-like, PH domain
Domain	IPR055251	SOS1/NGEF-like, PH domain
Family	IPR047271	Ephexin-like
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily

Domain Details Per Protein

Protein	Length	ARHGEF16/ARHGEF26, SH3 domain	Dbl homology (DH) domain superfamily	Ephexin-like	Ephexin-like, PH domain	PH-like domain superfamily	Pleckstrin homology domain	SH3 domain	SH3-like domain superfamily	SOS1/NGEF-like, PH domain
UniProtKB:A0A8M2BEQ4 InterPro	662
UniProtKB:B0S4U0 InterPro	606
UniProtKB:A0A8M9Q9S0 InterPro	359

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	arhgef16-201 (1) Ensembl	Ensembl	1,821 nt	Select Tool ZFIN BLAST
mRNA	arhgef16-202 (1) Ensembl	Ensembl	2,231 nt	Select Tool ZFIN BLAST
ncRNA	arhgef16-002 (1) Ensembl	Ensembl	760 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations