Gene
c7a
- ID
- ZDB-GENE-081104-392
- Name
- complement component 7a
- Symbol
- c7a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to be involved in complement activation. Predicted to act upstream of or within complement activation, classical pathway; cytolysis; and innate immune response. Predicted to be located in extracellular region. Predicted to be part of membrane attack complex. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in complement component 7 deficiency. Orthologous to human C7 (complement C7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| complement component 7 deficiency | Alliance | C7 deficiency | 610102 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020863 | Membrane attack complex component/perforin domain, conserved site |
| Conserved_site | IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| Domain | IPR000436 | Sushi/SCR/CCP domain |
| Domain | IPR003884 | Factor I / membrane attack complex |
| Domain | IPR020864 | Membrane attack complex component/perforin (MACPF) domain |
| Domain | IPR040729 | Kazal-type serine protease inhibitor domain |
| Domain | IPR048825 | Complement component C7, Kazal domain |
| Domain | IPR048831 | Complement components C8A/B/C6, EGF-like domain |
| Family | IPR001862 | Membrane attack complex component/perforin/complement C9 |
| Homologous_superfamily | IPR035976 | Sushi/SCR/CCP superfamily |
| Homologous_superfamily | IPR036055 | LDL receptor-like superfamily |
| Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
| Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
| Repeat | IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
Domain Details Per Protein
| Protein | Length | Complement component C7, Kazal domain | Complement components C8A/B/C6, EGF-like domain | Factor I / membrane attack complex | Kazal-type serine protease inhibitor domain | LDL receptor-like superfamily | Low-density lipoprotein (LDL) receptor class A, conserved site | Low-density lipoprotein (LDL) receptor class A repeat | Membrane attack complex component/perforin/complement C9 | Membrane attack complex component/perforin domain, conserved site | Membrane attack complex component/perforin (MACPF) domain | Sushi/SCR/CCP domain | Sushi/SCR/CCP superfamily | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AV96
|
857 | ||||||||||||||
|
UniProtKB:A0A8N7UT40
|
858 |
Interactions and Pathways
No data available
Plasmids
No data available