Gene
vwc2l
- ID
- ZDB-GENE-081104-169
- Name
- von Willebrand factor C domain containing 2 like
- Symbol
- vwc2l Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Acts upstream of or within nervous system development. Predicted to be located in extracellular region and synapse. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in extracellular space. Is expressed in forebrain; hindbrain; and midbrain. Orthologous to human VWC2L (von Willebrand factor C domain containing 2 like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Miwa et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Miwa et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la026981Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa16824 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-vwc2l | N/A | Miwa et al., 2009 |
| MO2-vwc2l | N/A | Miwa et al., 2009 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | von Willebrand factor C domain-containing protein 2-like | VWFC domain |
|---|---|---|---|
|
UniProtKB:B0UZC8
|
223 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-207D8 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128564 (1) | 896 nt | ||
| Genomic | GenBank:CR753890 (2) | 201771 nt | ||
| Polypeptide | UniProtKB:B0UZC8 (1) | 223 aa |
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Li, Q., Frank, M., Akiyama, M., Shimizu, H., Ho, S.Y., Thisse, C., Thisse, B., Sprecher, E., and Uitto, J. (2011) Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis. Disease models & mechanisms. 4(6):777-85
- Miwa, H., Miyake, A., Kouta, Y., Shimada, A., Yamashita, Y., Nakayama, Y., Yamauchi, H., Konishi, M., and Itoh, N. (2009) A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family. FEBS letters. 583(22):3643-3648
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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