Gene
lamb2
- ID
- ZDB-GENE-081030-4
- Name
- laminin, beta 2 (laminin S)
- Symbol
- lamb2 Nomenclature History
- Previous Names
-
- si:dkey-32e6.2
- sof
- softy (1)
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have extracellular matrix structural constituent and integrin binding activity. Involved in basement membrane assembly; muscle attachment; and somite development. Predicted to localize to laminin complex. Human ortholog(s) of this gene implicated in Pierson syndrome and nephrotic syndrome type 5. Is expressed in several structures, including adaxial cell; head; musculature system; nervous system; and solid lens vesicle. Orthologous to human LAMB2 (laminin subunit beta 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nephrotic syndrome type 5 | Alliance | Nephrotic syndrome, type 5, with or without ocular abnormalities | 614199 |
| Pierson syndrome | Alliance | Pierson syndrome | 609049 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | EGF-like domain | Laminin IV type B | Laminin, N-terminal | Laminin-type EGF domain |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B8V2
|
1794 | ||||
|
UniProtKB:B7ZDA6
|
1782 |
Interactions and Pathways
No data available
Plasmids
No data available