Gene
wnt7bb
- ID
- ZDB-GENE-081006-1
- Name
- wingless-type MMTV integration site family, member 7Bb
- Symbol
- wnt7bb Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within swim bladder formation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in brain; midbrain neural rod; presumptive diencephalon; and presumptive telencephalon. Orthologous to human WNT7B (Wnt family member 7B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Bouasker et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Wnt | Wnt-7 protein | Wnt, C-terminal domain | Wnt protein, conserved site |
|---|---|---|---|---|---|
|
UniProtKB:X1WEJ5
|
352 | ||||
|
UniProtKB:A0A8M6YYK6
|
275 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
wnt7bb-201
(1)
|
Ensembl | 2,834 nt | ||
| mRNA |
wnt7bb-202
(1)
|
Ensembl | 2,487 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-186K21 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-120A11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001920184 (1) | 2180 nt | ||
| Genomic | GenBank:CR385026 (2) | 85338 nt | ||
| Polypeptide | UniProtKB:X1WEJ5 (1) | 352 aa |
- Bouasker, S., Patel, N., Greenlees, R., Wellesley, D., Fares Taie, L., Almontashiri, N.A., Baptista, J., Alghamdi, M.A., Boissel, S., Martinovic, J., Prokudin, I., Holden, S., Mudhar, H.S., Riley, L.G., Nassif, C., Attie-Bitach, T., Miguet, M., Delous, M., Ernest, S., Plaisancié, J., Calvas, P., Rozet, J.M., Khan, A.O., Hamdan, F.F., Jamieson, R.V., Alkuraya, F.S., Michaud, J.L., Chassaing, N. (2022) Bi-allelic variants in WNT7B disrupt the development of multiple organs in humans. Journal of Medical Genetics. 60(3):294-300
- Kimura, K., Yamamori, S., Hazawa, M., Kobayashi-Sun, J., Kondo, M., Wong, R.W., Kobayashi, I. (2022) Inhibition of canonical Wnt signaling promotes ex vivo maintenance and proliferation of hematopoietic stem cells in zebrafish. Stem cells (Dayton, Ohio). 40(9):831-842
- Martin, M., Vermeiren, S., Bostaille, N., Eubelen, M., Spitzer, D., Vermeersch, M., Profaci, C.P., Pozuelo, E., Toussay, X., Raman-Nair, J., Tebabi, P., America, M., De Groote, A., Sanderson, L.E., Cabochette, P., Germano, R.F.V., Torres, D., Boutry, S., de Kerchove d'Exaerde, A., Bellefroid, E.J., Phoenix, T.N., Devraj, K., Lacoste, B., Daneman, R., Liebner, S., Vanhollebeke, B. (2022) Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders. Science (New York, N.Y.). 375:eabm4459
- Eubelen, M., Bostaille, N., Cabochette, P., Gauquier, A., Tebabi, P., Dumitru, A.C., Koehler, M., Gut, P., Alsteens, D., Stainier, D.Y.R., Garcia-Pino, A., Vanhollebeke, B. (2018) A molecular mechanism for Wnt ligand-specific signaling. Science (New York, N.Y.). 361(6403):
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Grainger, S., Richter, J., Palazón, R.E., Pouget, C., Lonquich, B., Wirth, S., Grassme, K.S., Herzog, W., Swift, M.R., Weinstein, B.M., Traver, D., Willert, K. (2016) Wnt9a Is Required for the Aortic Amplification of Nascent Hematopoietic Stem Cells. Cell Reports. 17:1595-1606
- Xu, Y.F., Liang, X., Chen, Y.R., Li, Y.F., Yang, J.L. (2016) Wnt7b gene expression and functional analysis in the mussel Mytilus coruscus. Genetics and molecular research : GMR. 15(4)
- Duncan, R.N., Panahi, S., Piotrowski, T., Dorsky, R.I. (2015) Identification of Wnt Genes Expressed in Neural Progenitor Zones during Zebrafish Brain Development. PLoS One. 10:e0145810
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Desvignes, T., Contreras, A., Postlethwait, J.H. (2014) Evolution of the miR199-214 cluster and vertebrate skeletal development. RNA Biology. 11(4):281-94
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