Gene
wnk1a
- ID
- ZDB-GENE-080917-49
- Name
- WNK lysine deficient protein kinase 1a
- Symbol
- wnk1a Nomenclature History
- Previous Names
-
- im:7165255
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have chloride channel inhibitor activity; potassium channel inhibitor activity; and protein serine/threonine kinase activity. Involved in angiogenesis. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2A; hereditary sensory neuropathy; hypertension; and pseudohypoaldosteronism. Is expressed in central nervous system; head; neural tube; notochord; and trunk. Orthologous to human WNK1 (WNK lysine deficient protein kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7165255 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Lai et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary sensory and autonomic neuropathy type 2A | Alliance | Neuropathy, hereditary sensory and autonomic, type II | 201300 |
| Pseudohypoaldosteronism, type IIC | 614492 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinase OSR1/WNK, CCT domain |
|---|---|---|---|---|---|
|
UniProtKB:X1WG08
|
1606 | ||||
|
UniProtKB:E7F2F9
|
1634 | ||||
|
UniProtKB:A0A8M3APR3
|
1633 | ||||
|
UniProtKB:A0A8M9PHD0
|
1264 | ||||
|
UniProtKB:A0A8M9QA82
|
1263 | ||||
|
UniProtKB:A0A8M1RI56
|
1605 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance