Gene

hpgd

ID

ZDB-GENE-080728-2

Name

15-hydroxyprostaglandin dehydrogenase

Symbol

hpgd Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have oxidoreductase activity. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hpgd Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary hypertrophic osteoarthropathy	Alliance	Cranioosteoarthropathy	259100
primary hypertrophic osteoarthropathy	Alliance	Hypertrophic osteoarthropathy, primary, autosomal recessive 1	259100
		?Digital clubbing, isolated congenital	119900

Associated With hpgd Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020904	Short-chain dehydrogenase/reductase, conserved site
Family	IPR002347	Short-chain dehydrogenase/reductase SDR
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily