Gene
eif2ak2
- ID
- ZDB-GENE-080422-1
- Name
- eukaryotic translation initiation factor 2-alpha kinase 2
- Symbol
- eif2ak2 Nomenclature History
- Previous Names
-
- PKR (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Enables protein kinase activity. Predicted to be involved in negative regulation of translation and regulation of translational initiation. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; dystonia 33; and hepatitis B. Orthologous to human EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Rothenburg et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR014720 | Double-stranded RNA-binding domain |
| Domain | IPR044452 | EIF2AK2, first double-stranded RNA binding domain |
| Family | IPR050339 | Cell Cycle and Stress Response Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Cell Cycle and Stress Response Kinase | Double-stranded RNA-binding domain | EIF2AK2, first double-stranded RNA binding domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A9YT50
|
682 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
eif2ak2-201
(1)
|
Ensembl | 2,075 nt |
Interactions and Pathways
No data available
Plasmids
No data available