Gene

nr0b2a

ID

ZDB-GENE-080403-1

Name

nuclear receptor subfamily 0, group B, member 2a

Symbol

nr0b2a Nomenclature History

Previous Names

NR0B2-A (1)
nr0b2a (1)
gb:bc058069
SHP-A (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have transcription corepressor activity and transcription factor binding activity. Predicted to be involved in circadian rhythm; negative regulation of DNA-binding transcription factor activity; and negative regulation of transcription by RNA polymerase II. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Is expressed in heart and yolk syncytial layer. Orthologous to human NR0B2 (nuclear receptor subfamily 0 group B member 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

bc058069 (3 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nr0b2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
obesity	Alliance	Obesity, mild, early-onset	601665

Associated With nr0b2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000536	Nuclear hormone receptor, ligand-binding domain
Family	IPR001723	Nuclear hormone receptor
Family	IPR033544	Nuclear receptor subfamily 0 group B member 1/2
Homologous_superfamily	IPR035500	Nuclear hormone receptor-like domain superfamily