ZFIN is now using GRCz12tu for Genomic Data
Gene
btr22
- ID
- ZDB-GENE-080402-4
- Name
- bloodthirsty-related gene family, member 22
- Symbol
- btr22 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ubiquitin-protein transferase activity and zinc ion binding activity. Predicted to act upstream of or within protein ubiquitination. Orthologous to several human genes including TRIM11 (tripartite motif containing 11); TRIM17 (tripartite motif containing 17); and TRIM39 (tripartite motif containing 39).
- Genome Resources
- Note
-
The bloodthirsty gene family (ubiquitin ligases) on chromosome 19 has been collapsed into fewer genes in GRCz12Tu compared to GRCz11. As a result, btr20 is no longer annotated in GRCz12Tu and its best alignment is to the annotated location of btr22; therefore, the gene records have been merged.
- Comparative Information
-
- All Expression Data
- 1 figure from Zhang et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa36751 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | B30.2/SPRY domain | B30.2/SPRY domain superfamily | B-box-type zinc finger | Butyrophylin-like, SPRY domain | Concanavalin A-like lectin/glucanase domain superfamily | E3 ubiquitin-protein ligase TRIM/RNF | SPRY-associated | SPRY domain | U-box domain | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site | Zinc finger, RING-type, eukaryotic |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB13A9M6 | InterPro | 520 | |||||||||||||
| UniProtKB:A0AB13AA62 | InterPro | 531 | |||||||||||||
| UniProtKB:A0A0R4IUT0 | InterPro | 544 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-206D17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136713 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:172108 | ZFIN Curated Data |
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- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423901 (1) | 2112 nt | ||
| Genomic | GenBank:CT030005 (2) | 126285 nt | ||
| Polypeptide | UniProtKB:A0A0R4IUT0 (1) | 544 aa |
No data available
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Zhang, X., Zhao, H., Chen, Y., Luo, H., Yang, P., Yao, B. (2015) A zebrafish (Danio rerio) bloodthirsty member 20 with E3 ubiquitin ligase activity involved in immune response against bacterial infection. Biochemical and Biophysical Research Communications. 457(1):83-9
- Boudinot, P., van der Aa, L.M., Jouneau, L., Du Pasquier, L., Pontarotti, P., Briolat, V., Benmansour, A., and Levraud, J.P. (2011) Origin and Evolution of TRIM Proteins: New Insights from the Complete TRIM Repertoire of Zebrafish and Pufferfish. PLoS One. 6(7):e22022
- van der Aa, L.M., Levraud, J.P., Yahmi, M., Lauret, E., Briolat, V., Herbomel, P., Benmansour, A., and Boudinot, P. (2009) A large new subset of TRIM genes highly diversified by duplication and positive selection in teleost fish. BMC Biology. 7:7
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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