Gene
tnmd
- ID
- ZDB-GENE-080220-31
- Name
- tenomodulin
- Symbol
- tnmd Nomenclature History
- Previous Names
-
- zgc:172161
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to be involved in negative regulation of angiogenesis and negative regulation of endothelial cell proliferation. Predicted to be located in membrane. Is expressed in several structures, including cleithrum; myoseptum; perichondrium; pharyngeal arch 1; and swim bladder. Orthologous to human TNMD (tenomodulin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la019028Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | BRICHOS domain | Chondromodulin/Tenomodulin |
|---|---|---|---|---|
| UniProtKB:A9JRD2 | InterPro | 301 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-57P8 | ZFIN Curated Data | |
| Contained in | BAC | CH211-234E22 | ||
| Encodes | cDNA | MGC:172161 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001114413 (1) | 2063 nt | ||
| Genomic | GenBank:BX510995 (2) | 169766 nt | ||
| Polypeptide | UniProtKB:A9JRD2 (1) | 301 aa |
- Miller, B.M., Goessling, W. (2024) The proteasome subunit psmb1 is essential for craniofacial cartilage maturation and morphogenesis. JCI insight. 9(16):
- Malbouyres, M., Guiraud, A., Lefrançois, C., Salamito, M., Nauroy, P., Bernard, L., Sohm, F., Allard, B., Ruggiero, F. (2022) Lack of the myotendinous junction marker col22a1 results in posture and locomotion disabilities in zebrafish. Matrix biology : journal of the International Society for Matrix Biology. 109:1-18
- Nie, C.H., Wan, S.M., Chen, Y.L., Huysseune, A., Wu, Y.M., Zhou, J.J., Hilsdorf, A.W.S., Wang, W.M., Witten, P.E., Lin, Q., Gao, Z.X. (2022) Single-cell transcriptomes and runx2b-/- mutants reveal the genetic signatures of intermuscular bone formation in zebrafish. National science review. 9:nwac152nwac152
- Xu, H., Tong, G., Yan, T., Dong, L., Yang, X., Dou, D., Sun, Z., Liu, T., Zheng, X., Yang, J., Sun, X., Zhou, Y., Kuang, Y. (2022) Transcriptomic Analysis Provides Insights to Reveal the bmp6 Function Related to the Development of Intermuscular Bones in Zebrafish. Frontiers in cell and developmental biology. 10:821471
- Chen, J.W., Niu, X., King, M.J., Noedl, M.T., Tabin, C.J., Galloway, J.L. (2020) The mevalonate pathway is a critical regulator of tendon cell specification. Development (Cambridge, England). 147(12):
- Kague, E., Hughes, S.M., A Lawrence, E., Cross, S., Martin-Silverstone, E., Hammond, C.L., Hinits, Y. (2019) Scleraxis genes are required for normal musculoskeletal development and for rib growth and mineralization in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(8):9116-9130
- Samarut, E., Chalopin, D., Riché, R., Allard, M., Liao, M., Drapeau, P. (2019) Individual knock out of glycine receptor alpha subunits identifies a specific requirement of glra1 for motor function in zebrafish. PLoS One. 14:e0216159
- Ma, R.C., Jacobs, C.T., Sharma, P., Kocha, K.M., Huang, P. (2018) Stereotypic generation of axial tenocytes from bipartite sclerotome domains in zebrafish. PLoS Genetics. 14:e1007775
- Godfrey, A., Hooser, B., Abdelmoneim, A., Horzmann, K.A., Freeman, J.L., Sepúlveda, M.S. (2017) Thyroid disrupting effects of halogenated and next generation chemicals on the swim bladder development of zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 193:228-235
- Bhandari, S., Lee, J.N., Kim, Y.I., Nam, I.K., Kim, S.J., Kim, S.J., Kwak, S., Oh, G.S., Kim, H.J., Yoo, H.J., So, H.S., Choe, S.K., Park, R. (2016) The fatty acid chain elongase, Elovl1, is required for kidney and swim bladder development during zebrafish embryogenesis. Organogenesis. 12(2):78-93
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