Gene

cblc

ID

ZDB-GENE-080220-20

Name

Cbl proto-oncogene C, E3 ubiquitin protein ligase

Symbol

cblc Nomenclature History

Previous Names

si:ch211-175g6.9
zgc:172162 (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of epidermal growth factor-activated receptor activity and signal transduction. Predicted to localize to membrane raft and plasma membrane. Orthologous to human CBLC (Cbl proto-oncogene C).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cblc Human Ortholog

No data available

Associated With cblc Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017907	Zinc finger, RING-type, conserved site
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR003153	Adaptor protein Cbl, N-terminal helical
Domain	IPR014741	Adaptor protein Cbl, EF hand-like
Domain	IPR014742	Adaptor protein Cbl, SH2-like domain
Domain	IPR024159	Adaptor protein Cbl, PTB domain
Family	IPR024162	Adaptor protein Cbl
Homologous_superfamily	IPR011992	EF-hand domain pair
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR036537	Adaptor protein Cbl, N-terminal domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily