Gene

mark2b

ID

ZDB-GENE-080215-4

Name

MAP/microtubule affinity-regulating kinase 2b

Symbol

mark2b Nomenclature History

Previous Names

mark2

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in intracellular signal transduction and microtubule cytoskeleton organization. Predicted to localize to cytoplasm. Orthologous to human MARK2 (microtubule affinity regulating kinase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mark2b Human Ortholog

No data available

Associated With mark2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001772	Kinase associated domain 1 (KA1)
Domain	IPR015940	Ubiquitin-associated domain
Domain	IPR049508	Serine/threonine-protein kinase MARK 1-4, catalytic domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR028375	KA1 domain/Ssp2, C-terminal

Domain Details Per Protein

Protein	Length	KA1 domain/Ssp2, C-terminal	Kinase associated domain 1 (KA1)	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site	Serine/threonine-protein kinase MARK 1-4, catalytic domain	Ubiquitin-associated domain
UniProtKB:A0A8M3B425 InterPro	781
UniProtKB:A0A8M3BAZ3 InterPro	768
UniProtKB:A0A8M3AU60 InterPro	741
UniProtKB:A0A8M3AU67 InterPro	777
UniProtKB:A0A8M3AU54 InterPro	789
UniProtKB:A0A8M3BAY8 InterPro	790
UniProtKB:A0A8M6Z7T9 InterPro	789
UniProtKB:A0A8M3B152 InterPro	780
UniProtKB:A0A8M3B429 InterPro	731

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mark2-201 (1) Ensembl	Ensembl	539 nt	Select Tool ZFIN BLAST
mRNA	mark2b-201 (1) Ensembl	Ensembl	2,343 nt	Select Tool ZFIN BLAST
mRNA	mark2b-202 (1) Ensembl	Ensembl	2,304 nt	Select Tool ZFIN BLAST
mRNA	mark2b-203 (1) Ensembl	Ensembl	655 nt	Select Tool ZFIN BLAST
mRNA	mark2b-205 (1) Ensembl	Ensembl	5,075 nt	Select Tool ZFIN BLAST
ncRNA	mark2b-003 (1) Ensembl	Ensembl	655 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations