Gene

fam135a

ID

ZDB-GENE-080130-1

Name

family with sequence similarity 135 member A

Symbol

fam135a Nomenclature History

Previous Names

im:7140207

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to be involved in lipid metabolic process. Orthologous to human FAM135A (family with sequence similarity 135 member A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7140207 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa11265	Allele with one point mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa14063	Allele with one point mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa16461	Allele with one point mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa38968	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa42274	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa42275	Allele with one point mutation	Unknown	Splice Site	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

1 - 6 of 6

Show

Sequence Targeting Reagents

No data available

Human Disease

Associated With fam135a Human Ortholog

No data available

Associated With fam135a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR007751	Domain of unknown function DUF676, lipase-like
Family	IPR022122	Protein FAM135
Family	IPR044294	Lipase-like
Homologous_superfamily	IPR029058	Alpha/Beta hydrolase fold

1 - 4 of 4

Domain Details Per Protein

Protein	Length	Alpha/Beta hydrolase fold	Domain of unknown function DUF676, lipase-like	Lipase-like	Protein FAM135
UniProtKB:A0A8M3B870 InterPro	1337
UniProtKB:A0A8M6Z2B8 InterPro	1317
UniProtKB:A0A8M6Z1Q6 InterPro	1343
UniProtKB:A0A8M2B344 InterPro	1311
UniProtKB:A0A8M6Z9L3 InterPro	1344

1 - 5 of 7 Show all

Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 13

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	fam135a-201 (1) Ensembl	Ensembl	4,017 nt	Select Tool ZFIN BLAST
mRNA	fam135a-202 (1) Ensembl	Ensembl	5,390 nt	Select Tool ZFIN BLAST
mRNA	fam135a-203 (1) Ensembl	Ensembl	481 nt	Select Tool ZFIN BLAST

1 - 3 of 3

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH73-226C13	CT737228	ZFIN Curated Data
Contained in	BAC	DKEY-85A20	BX324188	ZFIN Curated Data
Encodes	EST	IMAGE:7140207	CK678887	Thisse et al., 2004

1 - 3 of 3

Show

Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001145594 (1)	4017 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX324188 (1)	237686 nt	Select Tool MegaBLAST
Polypeptide	UniProtKB:A0A8M6Z9L3 (1)	1344 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	FAM135A	6	Ensembl:ENSG00000082269 Gene:57579 HGNC:21084	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)
Mouse	Fam135a	1	Ensembl:ENSMUSG00000026153 MGI:1915437 Gene:68187	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

1 - 1 of 1

Show