Gene

dock1

ID
ZDB-GENE-080108-5
Name
dedicator of cytokinesis 1
Symbol
dock1 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have GTPase activator activity and guanyl-nucleotide exchange factor activity. Involved in myelination in peripheral nervous system and myoblast fusion. Predicted to localize to integral component of membrane. Orthologous to human DOCK1 (dedicator of cytokinesis 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dock1 Human Ortholog
No data available
Associated With dock1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001452 SH3 domain
Domain IPR027007 C2 DOCK-type domain
Domain IPR027357 DOCKER domain
Domain IPR032376 Dedicator of cytokinesis, N-terminal domain
Domain IPR046769 DOCKER, Lobe A
Domain IPR046770 DOCKER, Lobe B
Domain IPR046773 DOCKER, Lobe C
Domain IPR047025 Dedicator of cytokinesis protein 1/5, SH3 domain
Domain IPR047026 Dedicator of cytokinesis protein 1, C2 domain
Family IPR026791 Dedicator of cytokinesis
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR035892 C2 domain superfamily
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR042455 Dedicator of cytokinesis, N-terminal, subdomain 1
Homologous_superfamily IPR043161 Dedicator of cytokinesis, C-terminal, lobe A
Homologous_superfamily IPR043162 Dedicator of cytokinesis, C-terminal, lobe C
Domain Details Per Protein
Protein Length Armadillo-type fold C2 DOCK-type domain C2 domain superfamily Dedicator of cytokinesis Dedicator of cytokinesis, C-terminal, lobe A Dedicator of cytokinesis, C-terminal, lobe C Dedicator of cytokinesis, N-terminal domain Dedicator of cytokinesis, N-terminal, subdomain 1 Dedicator of cytokinesis protein 1/5, SH3 domain Dedicator of cytokinesis protein 1, C2 domain DOCKER domain DOCKER, Lobe A DOCKER, Lobe B DOCKER, Lobe C SH3 domain SH3-like domain superfamily
UniProtKB:A8E1V6 1866
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA dock1-201 (1) Ensembl 5,523 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations