Gene

rhobtb2b

ID
ZDB-GENE-071125-1
Name
Rho related BTB domain containing 2b
Symbol
rhobtb2b Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including cytoskeleton organization; regulation of actin cytoskeleton organization; and regulation of cell shape. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be active in several cellular components, including cytoplasmic vesicle; cytoskeleton; and plasma membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 64. Orthologous to human RHOBTB2 (Rho related BTB domain containing 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-rhobtb2b
    		Varshney et al., 2015
    CRISPR2-rhobtb2b
      		Varshney et al., 2015
      1 - 2 of 2
      Show
      Human Disease
      Associated With rhobtb2b Human Ortholog
      Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
      developmental and epileptic encephalopathy 64 Alliance Developmental and epileptic encephalopathy 64 618004
      1 - 1 of 1
      Associated With rhobtb2b Via Experimental Models
      No data available
      Gene Ontology
      Protein Domains
      Domain, Family, and Site Summary
      Type InterPro ID Name
      Domain IPR000210 BTB/POZ domain
      Family IPR001806 Small GTPase
      Family IPR003578 Small GTPase Rho
      Homologous_superfamily IPR011333 SKP1/BTB/POZ domain superfamily
      Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
      1 - 5 of 5
      Domain Details Per Protein
      Protein Additional Resources Length BTB/POZ domain P-loop containing nucleoside triphosphate hydrolase SKP1/BTB/POZ domain superfamily Small GTPase Small GTPase Rho
      UniProtKB:E7F6W1 InterPro 714
      UniProtKB:A0A8M6Z0X0 InterPro 722
      1 - 2 of 2
      Transcripts
      Genome Browsers
      Type Name Annotation Method Has Havana Data Length (nt) Analysis
      mRNA rhobtb2b-201 (1)
      Ensembl
      		Ensembl 3,916 nt
      ZFIN BLAST
      mRNA rhobtb2b-202 (1)
      Ensembl
      		Ensembl 4,693 nt
      ZFIN BLAST
      mRNA rhobtb2b-203 (1)
      Ensembl
      		Ensembl 306 nt
      ZFIN BLAST
      1 - 3 of 3
      Interactions and Pathways
      No data available
      Antibodies
      No data available
      Plasmids
      No data available
      Constructs
      No data available
      Marker Relationships
      No data available
      Sequences
      Type Accession # Sequence Length (nt/aa) Analysis
      RNARefSeq:XM_017358113 (1)3486 nt
      ZFIN BLASTNCBI BLASTEnsemblUCSC BLAT
      GenomicGenBank:CABZ01063555 (1)30479 nt
      MegaBLASTEnsembl
      PolypeptideUniProtKB:A0A8M6Z0X0 (1)722 aa
      ZFIN BLASTSIB BLASTEnsembl Protein Blast
      Orthology
      Comparative Orthology
      Alliance
      Gene Tree
      Ensembl
      Citations
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