Gene
crfb15
- ID
- ZDB-GENE-071120-6
- Name
- cytokine receptor family member B15
- Symbol
- crfb15 Nomenclature History
- Previous Names
-
- si:ch73-222h13.4
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable cytokine receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in graft-versus-host disease; hepatitis B; and inflammatory bowel disease 25. Orthologous to human IL10RB (interleukin 10 receptor subunit beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-crfb15 | China Zebrafish Resource Center (CZRC) | |
| MO1-crfb15 | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR015373 | Interferon/interleukin receptor domain |
| Family | IPR050650 | Type II Cytokine and Tissue Factor Receptors |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | Interferon/interleukin receptor domain | Type II Cytokine and Tissue Factor Receptors |
|---|---|---|---|---|---|---|---|
| UniProtKB:D9IL85 | InterPro | 375 | |||||
| UniProtKB:A0A8M9PKP0 | InterPro | 386 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
crfb15-201
(1)
|
Ensembl | 587 nt | ||
| mRNA |
crfb15-202
(1)
|
Ensembl | 1,311 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-222H13 | ZFIN Curated Data | |
| Contained in | BAC | CH211-274B7 | ||
| Contained in | Fosmid | CH1073-100P20 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001278848 (1) | 1311 nt | ||
| Genomic | GenBank:BX323090 (1) | 166353 nt | ||
| Polypeptide | UniProtKB:A0A8M9PKP0 (1) | 386 aa |
No data available
- Deng, Y.H., Li, B., Chen, S.N., Ren, L., Zhang, B.D., Liu, L.H., Liu, S., Nie, P. (2023) Molecular characterization of nineteen cytokine receptor family B (CRFB) members, CRFB1, CRFB2, CRFB4-17, with three CRFB9 and two CRFB14 in a cyprinid fish, the blunt snout bream Megalobrama amblycephala. Developmental and comparative immunology. 145:104725
- Chen, S.N., Gan, Z., Hou, J., Yang, Y.C., Huang, L., Huang, B., Wang, S., Nie, P. (2022) Identification and establishment of type IV interferon and the characterization of interferon-υ including its class II cytokine receptors IFN-υR1 and IL-10R2. Nature communications. 13:999
- Chen, H., Liu, W., Wang, B., Mao, H., Sun, Z., Hou, Q., Mi, Y., Fan, L., Hu, C. (2015) Cloning, identification of the two cytokine receptor family B subunits CRFB1 and CRFB5 from grass carp (Ctenopharyngodon idella). Fish & shellfish immunology. 45(2):211-20
- He, M.D., Zhang, F.H., Wang, H.L., Wang, H.P., Zhu, Z.Y., Sun, Y.H. (2015) Efficient ligase 3-dependent microhomology-mediated end joining repair of DNA double-strand breaks in zebrafish embryos. Mutation research. 780:86-96
- Aggad, D., Stein, C., Sieger, D., Mazel, M., Boudinot, P., Herbomel, P., Levraud, J.P., Lutfalla, G., and Leptin, M. (2010) In Vivo Analysis of Ifn-γ1 and Ifn-γ2 Signaling in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 185(11):6774-6782
- Xue, Y., Kuok, C., Xiao, A., Zhu, Z., Lin, S., and Zhang, B. (2010) Identification and expression analysis of mical family genes in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 37(10):685-693
- Stein, C., Caccamo, M., Laird, G., and Leptin, M. (2007) Conservation and divergence of gene families encoding components of innate immune response systems in the zebrafish. Genome biology. 8(11):R251
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