Gene

nod1

ID

ZDB-GENE-071116-9

Name

nucleotide-binding oligomerization domain containing 1

Symbol

nod1 Nomenclature History

Previous Names

NLR-A1 (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to enable CARD domain binding activity and oligopeptide binding activity. Acts upstream of or within defense response to other organism; hatching behavior; and regulation of MAPK cascade. Predicted to be located in cytoplasm. Is expressed in brain; digestive system; gill; pleuroperitoneal region; and unfertilized egg. Human ortholog(s) of this gene implicated in asthma. Orthologous to human NOD1 (nucleotide binding oligomerization domain containing 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nod1 Human Ortholog

No data available

Associated With nod1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001315	CARD domain
Domain	IPR007111	NACHT nucleoside triphosphatase
Domain	IPR041075	NOD1/2, winged helix domain
Domain	IPR041267	NACHT, LRR and PYD domains-containing protein, helical domain HD2
Family	IPR052201	Leucine-rich repeat-containing regulator of pluripotency
Homologous_superfamily	IPR011029	Death-like domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Repeat	IPR001611	Leucine-rich repeat

Domain Details Per Protein

Protein	Length	CARD domain	Death-like domain superfamily	Leucine-rich repeat	Leucine-rich repeat-containing regulator of pluripotency	Leucine-rich repeat domain superfamily	NACHT, LRR and PYD domains-containing protein, helical domain HD2	NACHT nucleoside triphosphatase	NOD1/2, winged helix domain	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M1RMD1 InterPro	940

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	nod1-201 (1) Ensembl	Ensembl		3,097 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations