Gene
ciita
- ID
- ZDB-GENE-071116-6
- Name
- class II, major histocompatibility complex, transactivator
- Symbol
- ciita Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity. Predicted to be involved in inflammatory response and positive regulation of macromolecule biosynthetic process. Predicted to act upstream of or within regulation of DNA-templated transcription. Human ortholog(s) of this gene implicated in Addison's disease; MHC class II deficiency; autoimmune disease (multiple); and myocardial infarction. Orthologous to human CIITA (class II major histocompatibility complex transactivator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| MHC class II deficiency | Alliance | MHC class II deficiency 1 | 209920 |
| rheumatoid arthritis | Alliance | {Rheumatoid arthritis, susceptibility to} | 180300 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR007111 | NACHT nucleoside triphosphatase |
| Domain | IPR041267 | NACHT, LRR and PYD domains-containing protein, helical domain HD2 |
| Family | IPR008095 | MHC class II transactivator |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
Domain Details Per Protein
| Protein | Length | Leucine-rich repeat | Leucine-rich repeat domain superfamily | MHC class II transactivator | NACHT, LRR and PYD domains-containing protein, helical domain HD2 | NACHT nucleoside triphosphatase | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BB20
|
1138 | ||||||
|
UniProtKB:A0A8M3AQW0
|
1143 | ||||||
|
UniProtKB:E7F3F4
|
1044 |
Interactions and Pathways
No data available
Plasmids
No data available