Gene
ciita
- ID
- ZDB-GENE-071116-6
- Name
- class II, major histocompatibility complex, transactivator
- Symbol
- ciita Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have activating transcription factor binding activity. Predicted to be involved in inflammatory response and positive regulation of macromolecule biosynthetic process. Human ortholog(s) of this gene implicated in Addison's disease; MHC class II deficiency; autoimmune hypersensitivity disease (multiple); myocardial infarction; and rheumatoid arthritis (multiple). Orthologous to human CIITA (class II major histocompatibility complex transactivator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| MHC class II deficiency | Alliance | MHC class II deficiency 1 | 209920 |
| rheumatoid arthritis | Alliance | {Rheumatoid arthritis, susceptibility to} | 180300 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR007111 | NACHT nucleoside triphosphatase |
| Domain | IPR041267 | NACHT, LRR and PYD domains-containing protein, helical domain HD2 |
| Family | IPR008095 | MHC class II transactivator |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
Domain Details Per Protein
| Protein | Length | Leucine-rich repeat | Leucine-rich repeat domain superfamily | MHC class II transactivator | NACHT, LRR and PYD domains-containing protein, helical domain HD2 | NACHT nucleoside triphosphatase | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BB20
|
1138 | ||||||
|
UniProtKB:A0A8M3AQW0
|
1143 | ||||||
|
UniProtKB:E7F3F4
|
1044 |
Interactions and Pathways
No data available
Plasmids
No data available