Gene
adam10b
- ID
- ZDB-GENE-071115-1
- Name
- ADAM metallopeptidase domain 10b
- Symbol
- adam10b Nomenclature History
- Previous Names
-
- zgc:64203
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have metalloendopeptidase activity involved in amyloid precursor protein catabolic process. Predicted to be involved in Notch signaling pathway and PMA-inducible membrane protein ectodomain proteolysis. Predicted to localize to synaptic membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Alzheimer's disease 18 | Alliance | {Alzheimer disease 18, susceptibility to} | 615590 |
| reticulate acropigmentation of Kitamura | Alliance | Reticulate acropigmentation of Kitamura | 615537 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001590 | Peptidase M12B, ADAM/reprolysin |
| Domain | IPR001762 | Disintegrin domain |
| Domain | IPR034025 | ADAM10/ADAM17 catalytic domain |
| Family | IPR051489 | Disintegrin and Metalloproteinase Domain-Containing |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR036436 | Disintegrin domain superfamily |
Domain Details Per Protein
| Protein | Length | ADAM10/ADAM17 catalytic domain | Disintegrin and Metalloproteinase Domain-Containing | Disintegrin domain | Disintegrin domain superfamily | Metallopeptidase, catalytic domain superfamily | Peptidase M12B, ADAM/reprolysin |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PGZ4
|
669 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available