Gene

fars2

ID

ZDB-GENE-070928-38

Name

phenylalanyl-tRNA synthetase 2, mitochondrial

Symbol

fars2 Nomenclature History

Previous Names

zgc:173439

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have phenylalanine-tRNA ligase activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 14 and hereditary spastic paraplegia 77. Orthologous to human FARS2 (phenylalanyl-tRNA synthetase 2, mitochondrial).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fars2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
combined oxidative phosphorylation deficiency 14	Alliance	Combined oxidative phosphorylation deficiency 14	614946
hereditary spastic paraplegia 77	Alliance	Spastic paraplegia 77, autosomal recessive	617046

Associated With fars2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002319	Phenylalanyl-tRNA synthetase
Domain	IPR005121	Ferrodoxin-fold anticodon-binding domain
Domain	IPR006195	Aminoacyl-tRNA synthetase, class II
Family	IPR004530	Phenylalanyl-tRNA synthetase, class IIc, mitochondrial
Homologous_superfamily	IPR036690	Ferrodoxin-fold anticodon-binding domain superfamily
Homologous_superfamily	IPR045864	Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)