Gene
egf
- ID
- ZDB-GENE-070922-1
- Name
- epidermal growth factor
- Symbol
- egf Nomenclature History
- Previous Names
-
- sb:eu639
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to have Wnt-activated receptor activity and Wnt-protein binding activity. Involved in blood circulation and cartilage development. Predicted to localize to plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); lung cancer (multiple); malignant glioma (multiple); and primary hypomagnesemia (multiple). Is expressed in several structures, including central nervous system; notochord; opercular flap; pleuroperitoneal region; and scale. Orthologous to human EGF (epidermal growth factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu639 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Pruvot et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| renal hypomagnesemia 4 | Alliance | ?Hypomagnesemia 4, renal | 611718 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR024731 | EGF domain |
| Domain | IPR049883 | NOTCH1 EGF-like calcium-binding domain |
| Family | IPR016317 | Pro-epidermal growth factor |
| Family | IPR050778 | Cueball/EGF/LRP/Nidogen |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR011042 | Six-bladed beta-propeller, TolB-like |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
| Repeat | IPR000033 | LDLR class B repeat |
Domain Details Per Protein
| Protein | Length | Cueball/EGF/LRP/Nidogen | EGF domain | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | LDLR class B repeat | NOTCH1 EGF-like calcium-binding domain | Pro-epidermal growth factor | Six-bladed beta-propeller, TolB-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6VQA2
|
1114 | |||||||||||
|
UniProtKB:A0A8M9QAZ6
|
1138 | |||||||||||
|
UniProtKB:A0A8M9PZ53
|
1176 |
Interactions and Pathways
Plasmids
No data available