Gene
scn2b
- ID
- ZDB-GENE-070920-1
- Name
- sodium channel, voltage-gated, type II, beta
- Symbol
- scn2b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable sodium channel regulator activity. Predicted to be involved in cardiac conduction; cardiac muscle cell action potential involved in contraction; and membrane depolarization during cardiac muscle cell action potential. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in plasma membrane. Is expressed in atrium; brain; cardiac ventricle; and eye. Human ortholog(s) of this gene implicated in familial atrial fibrillation. Orthologous to human SCN2B (sodium voltage-gated channel beta subunit 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Chopra et al., 2007
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial atrial fibrillation | Alliance | Atrial fibrillation, familial, 14 | 615378 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013106 | Immunoglobulin V-set domain |
| Family | IPR000920 | Myelin P0 protein-related |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin V-set domain | Myelin P0 protein-related |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q06W28
|
230 |
Interactions and Pathways
No data available
Plasmids
No data available