Gene

otulinb

ID

ZDB-GENE-070912-627

Name

OTU deubiquitinase with linear linkage specificity b

Symbol

otulinb Nomenclature History

Previous Names

fam105bb
si:dkeyp-106c5.3
wu:fc69a03

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to enable cysteine-type deubiquitinase activity. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in otulipenia and primary immunodeficiency disease. Orthologous to several human genes including OTULIN (OTU deubiquitinase with linear linkage specificity).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7144154 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With otulinb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
immunodeficiency 107	Alliance	{Immunodeficiency 107, susceptibility to invasive staphylococcus aureus infection}	619986
otulipenia	Alliance	Autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive	617099
		Autoinflammation, panniculitis, and dermatosis syndrome, autosomal dominant	621030

Associated With otulinb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR023235	FAM105
Family	IPR023236	Inactive ubiquitin thioesterase OTULINL

Domain Details Per Protein

Protein	Length	FAM105	Inactive ubiquitin thioesterase OTULINL
UniProtKB:A0A8M3B0B6 InterPro	349
UniProtKB:A0A8M2BAN8 InterPro	409

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	otulinb-203 (1) Ensembl	Ensembl	661 nt	Select Tool ZFIN BLAST
mRNA	otulinb-204 (1) Ensembl	Ensembl	906 nt	Select Tool ZFIN BLAST
mRNA	otulinb-206 (1) Ensembl	Ensembl	1,761 nt	Select Tool ZFIN BLAST
ncRNA	otulinb-003 (1) Ensembl	Ensembl	817 nt	Select Tool ZFIN BLAST
ncRNA	otulinb-004 (1) Ensembl	Ensembl	904 nt	Select Tool ZFIN BLAST
ncRNA	otulinb-006 (1) Ensembl	Ensembl	764 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations