Gene

serpine1

ID

ZDB-GENE-070912-60

Name

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

Symbol

serpine1 Nomenclature History

Previous Names

PAI-1 (1)
si:ch211-138a11.1

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Enables serine-type endopeptidase inhibitor activity. Acts upstream of or within negative regulation of plasminogen activation. Predicted to be active in extracellular space. Is expressed in bulbus arteriosus and heart. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 11 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Han et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With serpine1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Plasminogen activator inhibitor-1 deficiency	613329
		{Transcription of plasminogen activator inhibitor, modulator of}

Associated With serpine1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023795	Serpin, conserved site
Domain	IPR023796	Serpin domain
Family	IPR000215	Serpin family
Homologous_superfamily	IPR036186	Serpin superfamily
Homologous_superfamily	IPR042178	Serpin superfamily, domain 1
Homologous_superfamily	IPR042185	Serpin superfamily, domain 2